tert-Butylsulfinamide, (R)-(+)- → HCID 89875638, compound

HRID 715404Notes

Reaction equation

HRID 715404 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([C:13](=O)[CH3:14])=[CH:9][C:8]=2[CH3:16])=[CH:4][CH:3]=1.[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[N:12]=[CH:11][C:10]([CH:13]([NH:25][S@@:23]([C:20]([CH3:22])([CH3:21])[CH3:19])=[O:24])[CH3:14])=[CH:9][C:8]=2[CH3:16])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874487HCID 89874487, compound

Product 1

HCID 89875638HCID 89875638, compoundYield 76%

Procedure

The title compound is prepared in 76% yield (2.67 g, white solid) from 1-(6-(4-fluorophenoxy)-5-methylpyridin-3-yl)ethanone (2.47 g, 10.1 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.83 g, 15.1 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-eb3f07bc1e4849108ec9f24321842717
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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