tert-Butylsulfinamide, (R)-(+)- → HCID 89875555, compound

HRID 715405Notes

Reaction equation

HRID 715405 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[N:11]=[CH:10][C:9]([C:12](=O)[CH3:13])=[CH:8][C:7]=1[CH3:15].[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[N:11]=[CH:10][C:9]([CH:12]([NH:25][S@@:23]([C:20]([CH3:22])([CH3:21])[CH3:19])=[O:24])[CH3:13])=[CH:8][C:7]=1[CH3:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874346HCID 89874346, compound

Product 1

HCID 89875555HCID 89875555, compoundYield 79%

Procedure

The title compound is prepared in 79% yield (1.27 g, colorless amorphous) from 1-(6-(3-fluorophenoxy)-5-methylpyridin-3-yl)ethanone (1.13 g, 4.61 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (838 mg, 6.91 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-114d607c4ce44bfabcbfac0567392581
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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