tert-Butylsulfinamide, (R)-(+)- → HCID 89874578, compound

HRID 715406Notes

Reaction equation

HRID 715406 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:19](=O)[CH3:20])[CH:5]=[N:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=1.[CH3:22][C:23]([S@:26]([NH2:28])=[O:27])([CH3:25])[CH3:24]>>[CH3:22][C:23]([S@:26]([NH:28][CH:19]([C:4]1[CH:5]=[N:6][C:7]([O:8][C:9]2[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)=[C:2]([CH3:1])[CH:3]=1)[CH3:20])=[O:27])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874432HCID 89874432, compound

Product 1

HCID 89874578HCID 89874578, compoundYield 73%

Procedure

The title compound is prepared in 73% yield (1.67 g, colorless amorphous) from 1-(5-methyl-6-((6-(trifluoromethyl)pyridin-3-yl)oxy)pyridin-3-yl)ethanone (1.69 g, 5.70 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.04 g, 8.56 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-786baca6616446dfa24930eaa24fb32a
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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