tert-Butylsulfinamide, (R)-(+)- → HCID 89875351, compound

HRID 715407Notes

Reaction equation

HRID 715407 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][C:10]=2[CH3:18])=[CH:4][CH:3]=1.[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:14]=[CH:13][C:12]([CH:15]([NH:25][S@@:23]([C:20]([CH3:22])([CH3:21])[CH3:19])=[O:24])[CH3:16])=[CH:11][C:10]=2[CH3:18])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874975HCID 89874975, compound

Product 1

HCID 89875351HCID 89875351, compoundYield 74%

Procedure

The title compound is prepared in 74% yield (2.82 g, white solid) from 1-(6-((4-fluorophenyl)thio)-5-methylpyridin-3-yl)ethanone (2.71 g, 10.4 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.89 g, 15.6 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-86ef9a40c03340f5b366bee29becf110
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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