tert-Butylsulfinamide, (R)-(+)- → HCID 89874519, compound

HRID 715409Notes

Reaction equation

HRID 715409 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[N:11]=[CH:10][C:9]([C:12](=O)[CH3:13])=[CH:8][C:7]=1[CH3:15].[CH3:20][C:21]([S@:24]([NH2:26])=[O:25])([CH3:23])[CH3:22]>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[N:11]=[CH:10][C:9]([CH:12]([NH:26][S@@:24]([C:21]([CH3:23])([CH3:22])[CH3:20])=[O:25])[CH3:13])=[CH:8][C:7]=1[CH3:15]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875236HCID 89875236, compound

Product 1

HCID 89874519HCID 89874519, compoundYield 73%

Procedure

The title compound is prepared in 73% yield (2.03 g, white solid) from 1-(6-(3,4-difluorophenoxy)-5-methylpyridin-3-yl)ethanone (2.00 g, 7.60 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.38 g, 11.4 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-72b51a2c52144b7da44ebc66c3979ca1
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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