tert-Butylsulfinamide, (R)-(+)- → HCID 89874878, compound

HRID 715411Notes

Reaction equation

HRID 715411 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[CH:11][C:10]([C:13](=O)[CH3:14])=[CH:9][C:8]=2[CH3:16])[CH:6]=1.[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[Cl:1][C:2]1[CH:3]=[N:4][N:5]([C:7]2[N:12]=[CH:11][C:10]([CH:13]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:14])=[CH:9][C:8]=2[CH3:16])[CH:6]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89873818HCID 89873818, compound

Product 1

HCID 89874878HCID 89874878, compoundYield 57%

Procedure

The title compound is prepared in 57% yield (1.08 g, colorless amorphous) from 1-(6-(4-chloro-1H-pyrazol-1-yl)-5-methylpyridin-3-yl)ethanone (1.30 g, 5.52 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.00 g, 8.27 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-e815ed79c7fc40248dcd0f52e210aae8
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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