tert-Butylsulfinamide, (R)-(+)- → HCID 89874496, compound

HRID 715414Notes

Reaction equation

HRID 715414 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:17](=O)[CH3:18])[CH:5]=[N:6][C:7]=1[N:8]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[N:9]1.[CH3:20][C:21]([S@:24]([NH2:26])=[O:25])([CH3:23])[CH3:22]>>[CH3:20][C:21]([S@:24]([NH:26][CH:17]([C:4]1[CH:5]=[N:6][C:7]([N:8]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[N:9]2)=[C:2]([CH3:1])[CH:3]=1)[CH3:18])=[O:25])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874341HCID 89874341, compound

Product 1

HCID 89874496HCID 89874496, compoundYield 78%

Procedure

The title compound is prepared in 78% yield (2.16 g, yellows oil) from 1-(5-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-3-yl)ethanone (2.00 g, 7.43 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (1.35 g, 11.1 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-89ea3d58c8c94ca2916e16a35adf3763
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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