Aluminium lithium hydride → HCID 89875399, compound

HRID 715418Notes

Reaction equation

HRID 715418 reaction equation
CON(C)[C:4](=[O:18])[C:5]1[CH:10]=[C:9]([CH3:11])[C:8]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[CH:7][N:6]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:11][C:9]1[C:8]([O:12][CH2:13][C:14]([F:17])([F:15])[F:16])=[CH:7][N:6]=[C:5]([CH:4]=[O:18])[CH:10]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 89874977HCID 89874977, compound

Product 1

HCID 89875399HCID 89875399, compoundYield 95%

Procedure

The title compound is prepared in 95% yield (1.2 g, a pale brown solid) from N-methoxy-N,4-dimethyl-5-(2,2,2-trifluoroethoxy)picolinamide (1.6 g, 5.8 mmol, Step-2) and lithium aluminum hydride (80 mg, 2.9 mmol) in a similar manner to Step-2 of Amine-3.

Sources & evidence

ORD record
ord-d08c73be43ad4c3f83e4b2844a88f24c
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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