Dodecylamine → HCID 89874072, compound

HRID 715426Notes

Reaction equation

HRID 715426 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[O:20][CH2:21][C:22]([F:25])([F:24])[F:23])[CH2:5][N:6]1C(=O)C2C(=CC=CC=2)C1=O.CCCCCCCCCCCCN>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH2:5][NH2:6])[CH:17]=[CH:18][C:19]=1[O:20][CH2:21][C:22]([F:24])([F:25])[F:23]

Participants

3

Reactant 2

HCID 13583DodecylamineHCID 89874734HCID 89874734, compound

Product 1

HCID 89874072HCID 89874072, compoundYield 89%

Procedure

The title compound is prepared in 89% yield (593 mg, an off-white solid) from 2-(3-chloro-4-(2,2,2-trifluoroethoxy)benzyl)isoindoline-1,3-dione (890 mg, 2.41 mmol, Step-2) in a similar manner to Step-5 of Amine-12.

Sources & evidence

ORD record
ord-2eef155ba1c84f67aba87cbe673147a5
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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