tert-Butylsulfinamide, (R)-(+)- → HCID 89874373, compound

HRID 715428Notes

Reaction equation

HRID 715428 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8](=O)[CH3:9])[CH:5]=[N:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[CH3:17][C:18]([S@:21]([NH:23][CH:8]([C:6]1[CH:5]=[N:4][C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[C:2]([CH3:1])[N:7]=1)[CH3:9])=[O:22])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875315HCID 89875315, compound

Product 1

HCID 89874373HCID 89874373, compoundYield 68%

Procedure

The title compound is prepared in 68% yield (347 mg, a pale brown oil) from 1-(6-methyl-5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)ethanone (350 mg, 1.50 mmol, Step-4) and (R)-2-methylpropane-2-sulfinamide (217 mg, 1.79 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-e7f87c871c4e43de8253ef2c0c5c607e
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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