Dodecylamine → HCID 89874838, compound

HRID 715432Notes

Reaction equation

HRID 715432 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])=[CH:6][N:5]=[C:4]([CH2:15][N:16]2C(=O)C3C(=CC=CC=3)C2=O)[CH:3]=1.CCCCCCCCCCCCN>>[CH3:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][C:11]([F:14])([F:12])[F:13])=[CH:6][N:5]=[C:4]([CH2:15][NH2:16])[CH:3]=1

Participants

3

Reactant 2

HCID 13583DodecylamineHCID 89875406HCID 89875406, compound

Product 1

HCID 89874838HCID 89874838, compoundYield 69%

Procedure

The title compound is prepared in 69% yield (133 mg, a pale brown oil) from 2-((4-methyl-5-(3,3,3-trifluoropropoxy)pyridin-2-yl)methyl)isoindoline-1,3-dione (300 mg, 0.82 mmol, Step-4) in a similar manner to Step-5 of Amine-12.

Sources & evidence

ORD record
ord-ddd7653dbecc43d7837d1fbba198c22c
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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