2,2,3,3-Tetrafluoro-1-propanol → HCID 43128665, compound

HRID 715434Notes

Reaction equation

HRID 715434 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][C:13]([F:19])([CH:16]([F:18])[F:17])[CH2:14][OH:15]>>[Cl:1][C:2]1[C:3]([O:15][CH2:14][C:13]([F:19])([F:12])[CH:16]([F:18])[F:17])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 64412,2,3,3-Tetrafluoro-1-propanolHCID 2479875,6-Dichloronicotinic acid

Product 1

HCID 43128665HCID 43128665, compoundYield 97%

Procedure

The title compound is prepared in 97% yield (7.29 g, a pale brown solid) from 5,6-dichloronicotinic acid (5.00 g, 26.0 mmol) and 2,2,3,3-tetrafluoropropan-1-ol (5.16 g, 39.1 mmol) in a similar manner to Step-1 of Amine-1.

Sources & evidence

ORD record
ord-6390c80f0850448190d55240a9c12fcd
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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