tert-Butylsulfinamide, (R)-(+)- → HCID 89874444, compound

HRID 715435Notes

Reaction equation

HRID 715435 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:16](=O)[CH3:17])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12].[CH3:19][C:20]([S@:23]([NH2:25])=[O:24])([CH3:22])[CH3:21]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]([NH:25][S@@:23]([C:20]([CH3:22])([CH3:21])[CH3:19])=[O:24])[CH3:17])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874663HCID 89874663, compound

Product 1

HCID 89874444HCID 89874444, compoundYield 81%

Procedure

The title compound is prepared in 81% yield (5.11 g, white solid) from 1-(5-chloro-6-(2,2,3,3-tetrafluoropropoxy)pyridin-3-yl)ethanone (4.62 g, 16.2 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide (2.94 g, 24.3 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-c0715fcaebcb4893853fdd4adc4ba3dd
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

Loading…