3,3,3-Trifluoro-1-propanol → HCID 82956186, compound

HRID 715436Notes

Reaction equation

HRID 715436 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:12][C:13]([F:18])([F:17])[CH2:14][CH2:15][OH:16]>>[Cl:1][C:2]1[C:3]([O:16][CH2:15][CH2:14][C:13]([F:18])([F:17])[F:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 1375123,3,3-Trifluoro-1-propanolHCID 2479875,6-Dichloronicotinic acid

Product 1

HCID 82956186HCID 82956186, compoundYield 66%

Procedure

The title compound is prepared in 66% yield (6.48 g, white solid) from 5,6-dichloronicotinic acid (7.00 g, 36.5 mmol) and 3,3,3-trifluoropropan-1-ol (8.32 g, 72.9 mmol) in a similar manner to Step-1 of Amine-1.

Sources & evidence

ORD record
ord-47f52eeb4c1548dbb4b64c2e5877e7b4
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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