tert-Butylsulfinamide, (R)-(+)- → HCID 89875283, compound

HRID 715445Notes

Reaction equation

HRID 715445 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:15](=O)[CH3:16])[CH:5]=[N:6][C:7]=1[CH2:8][O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]([NH:24][S@@:22]([C:19]([CH3:21])([CH3:20])[CH3:18])=[O:23])[CH3:16])[CH:5]=[N:6][C:7]=1[CH2:8][O:9][CH2:10][C:11]([F:14])([F:13])[F:12]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874624HCID 89874624, compound

Product 1

HCID 89875283HCID 89875283, compoundYield 82%

Procedure

The title compound is prepared in 82% yield (827 mg, yellows oil) from 1-(5-chloro-6-((2,2,2-trifluoroethoxy)methyl)pyridin-3-yl)ethanone (720 mg, 2.69 mmol, Step-6) and (R)-2-methylpropane-2-sulfinamide (489 mg, 4.04 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-ab8024815e5d41c884a1e0fbd2d195e7
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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