tert-Butylsulfinamide, (R)-(+)- → HCID 89874474, compound

HRID 715449Notes

Reaction equation

HRID 715449 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][C:9]([C:12](=O)[CH3:13])=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][C:9]([CH:12]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:13])=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874679HCID 89874679, compound

Product 1

HCID 89874474HCID 89874474, compoundYield 85%

Procedure

The title compound is prepared in 85% yield (4.10 g, colorless oil) from 1-(6-(cyclopropylmethoxy)-5-methylpyridin-3-yl)ethanone (3.18 g, 15.5 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide (2.82 g, 23.3 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-46f40e2915a24b37a74fa1ffd8975bfd
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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