tert-Butylsulfinamide, (R)-(+)- → HCID 89875446, compound

HRID 715450Notes

Reaction equation

HRID 715450 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[N:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][C:9]=2[CH3:17])=[CH:4][CH:3]=1.[CH3:20][C:21]([S@:24]([NH2:26])=[O:25])([CH3:23])[CH3:22]>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[N:13]=[CH:12][C:11]([CH:14]([NH:26][S@@:24]([C:21]([CH3:23])([CH3:22])[CH3:20])=[O:25])[CH3:15])=[CH:10][C:9]=2[CH3:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875375HCID 89875375, compound

Product 1

HCID 89875446HCID 89875446, compoundYield 79%

Procedure

The title compound is prepared in 79% yield (2.15 g, white solid) from 1-(6-((4-fluorobenzyl)oxy)-5-methylpyridin-3-yl)ethanone (1.94 g, 7.48 mmol, Step-3) and (R)-2-methylpropane-2-sulfinamide (1.36 g, 11.2 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-e4bcc184edf9490195eacca86e3197ef
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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