tert-Butylsulfinamide, (R)-(+)- → HCID 89874636, compound

HRID 715453Notes

Reaction equation

HRID 715453 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])=[CH:6][N:5]=[C:4]([CH:16]=O)[CH:3]=1.[CH3:18][C:19]([S@:22]([NH2:24])=[O:23])([CH3:21])[CH3:20]>>[CH3:18][C:19]([S@:22](/[N:24]=[CH:16]/[C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([O:8][CH2:9][C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])=[CH:6][N:5]=1)=[O:23])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875398HCID 89875398, compound

Product 1

HCID 89874636HCID 89874636, compoundYield 81%

Procedure

The title compound is prepared in 81% yield (1.38 g, pale yellow solid) from 4-methyl-5-(2,2,3,3-tetrafluoropropoxy)picolinaldehyde (1.20 g, 4.79 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (872 mg, 7.19 mmol) in a similar manner to Step-6 of Amine-49.

Sources & evidence

ORD record
ord-f20dcdae030d41eb8d25814c93dc2b0c
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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