tert-Butylsulfinamide, (R)-(+)- → HCID 89874967, compound

HRID 715456Notes

Reaction equation

HRID 715456 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[C:7]([CH3:14])=[CH:8][C:9]([CH:12]=O)=[N:10][CH:11]=2)[CH2:3][CH2:2]1.[CH3:15][C:16]([S@:19]([NH2:21])=[O:20])([CH3:18])[CH3:17]>>[CH:1]1([CH2:4][O:5][C:6]2[C:7]([CH3:14])=[CH:8][C:9](/[CH:12]=[N:21]/[S@@:19]([C:16]([CH3:18])([CH3:17])[CH3:15])=[O:20])=[N:10][CH:11]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89874839HCID 89874839, compound

Product 1

HCID 89874967HCID 89874967, compoundYield 90%

Procedure

The title compound is prepared in 90% yield (688 mg, yellow oil) from 5-(cyclopropylmethoxy)-4-methylpicolinaldehyde (495 mg, 2.59 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (471 mg, 3.88 mmol) in a similar manner to Step-6 of Amine-49.

Sources & evidence

ORD record
ord-c87e3d534c7643339f5e31525fe1714d
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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