HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclobutanol → 6-Cyclobutoxy-5-methylnicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclobutanol | HCID 76218 | — |
| Reactant | 6-Fluoro-5-methylpyridine-3-carboxylic acid | HCID 16414223 | — |
| Product | 6-Cyclobutoxy-5-methylnicotinic acid | HCID 89874304 | 88% |
Reaction Steps
The title compound is prepared in 88% yield (1.18 g, white solid) from 6-fluoro-5-methylnicotinic acid (1.00 g, 6.45 mmol) and cyclobutanol (837 mg, 11.6 mmol) in a similar manner to Step-1 of Amine-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a800879334514e89957156ffc0540ca4 |
| Source note | uspto-grants-2015_11 |