tert-Butylsulfinamide, (R)-(+)- → HCID 89875123, compound

HRID 715463Notes

Reaction equation

HRID 715463 reaction equation
[F:1][C:2]([F:15])([CH3:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8]([CH:11]=O)=[N:9][CH:10]=1.[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[F:1][C:2]([F:15])([CH3:14])[CH2:3][O:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8](/[CH:11]=[N:22]/[S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875029HCID 89875029, compound

Product 1

HCID 89875123HCID 89875123, compoundYield 74%

Procedure

The title compound is prepared in 74% yield (1.10 g, pale yellow solid) from 5-(2,2-difluoropropoxy)-4-methylpicolinaldehyde (1.01 g, 4.68 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (851 mg, 7.02 mmol) in a similar manner to Step-6 of Amine-49.

Sources & evidence

ORD record
ord-d13b3098751f40ed8dc3a6766d60a099
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

Loading…