tert-Butylsulfinamide, (R)-(+)- → HCID 89874499, compound

HRID 715465Notes

Reaction equation

HRID 715465 reaction equation
[F:1][C:2]([F:16])([CH3:15])[CH2:3][O:4][C:5]1[N:10]=[N:9][C:8]([C:11](=O)[CH3:12])=[CH:7][C:6]=1[CH3:14].[CH3:17][C:18]([S@:21]([NH2:23])=[O:22])([CH3:20])[CH3:19]>>[F:1][C:2]([F:16])([CH3:15])[CH2:3][O:4][C:5]1[N:10]=[N:9][C:8]([CH:11]([NH:23][S@@:21]([C:18]([CH3:20])([CH3:19])[CH3:17])=[O:22])[CH3:12])=[CH:7][C:6]=1[CH3:14]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 89875302HCID 89875302, compound

Product 1

HCID 89874499HCID 89874499, compoundYield 74%

Procedure

The title compound is prepared in 74% yield (928 mg, yellow solid) from 1-(6-(2,2-difluoropropoxy)-5-methylpyridazin-3-yl)ethanone (860 mg, 3.74 mmol, Step-5) and (R)-2-methylpropane-2-sulfinamide (679 mg, 5.60 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-a4e0de04566e45fb9b9405ab37e23645
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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