tert-Butylsulfinamide, (R)-(+)- → HCID 89874099, compound

HRID 715469Notes

Reaction equation

HRID 715469 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[CH3:16][C:17]([S@:20]([NH:22][CH:13]([C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[C:2]([CH3:1])[CH:3]=1)[CH3:14])=[O:21])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 23210419HCID 23210419, compound

Product 1

HCID 89874099HCID 89874099, compoundYield 66%

Procedure

The title compound is prepared in 66% yield (971 mg, colorless oil) from 1-(3-methyl-4-(trifluoromethoxy)phenyl)ethanone (1.00 g, 4.58 mmol, Step-2) and (R)-2-methylpropane-2-sulfinamide (833 mg, 6.88 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-4cde541dc45549f39a84fd635267cddc
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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