tert-Butylsulfinamide, (R)-(+)- → HCID 89875246, compound

HRID 715473Notes

Reaction equation

HRID 715473 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:13](=O)[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[CH3:16][C:17]([S@:20]([NH2:22])=[O:21])([CH3:19])[CH3:18]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]([NH:22][S@@:20]([C:17]([CH3:19])([CH3:18])[CH3:16])=[O:21])[CH3:14])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10]

Participants

3

Reactant 2

HCID 10964479tert-Butylsulfinamide, (R)-(+)-HCID 147932731-[3-Chloro-4-(trifluoromethoxy)phenyl]ethan-1-one

Product 1

HCID 89875246HCID 89875246, compoundYield 81%

Procedure

The title compound is prepared in 81% yield (1.41 g, colorless oil) from 1-(3-chloro-4-(trifluoromethoxy)phenyl)ethanone (1.20 g, 5.03 mmol) and (R)-2-methylpropane-2-sulfinamide (914 mg, 7.54 mmol) in a similar manner to Step-4 of Amine-1.

Sources & evidence

ORD record
ord-93309b9c33a7425bb7eb1342d35d732c
Source dataset
uspto-grants-2015_11
Patent number
US09187475B2

Reaction notes

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