HuagongsheHuagongshe Chemistry Print Report · For research reference only
Decylamine → Methyl 3-chloro-4-(2,2-difluoropropoxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Decylamine | HCID 8916 | — |
| Reactant | Methyl 3-chloro-4-hydroxybenzoate | HCID 77580 | — |
| Reactant | 2,2-Difluoropropyl 1,1,1-trifluoromethanesulfonate | HCID 58747012 | — |
| Product | Methyl 3-chloro-4-(2,2-difluoropropoxy)benzoate | HCID 89874714 | 54% |
Reaction Steps
The title compound is prepared in 54% yield (1.54 g, white solid) from methyl 3-chloro-4-hydroxybenzoate (2.00 g, 10.7 mmol) and 2,2-difluoropropyl trifluoromethanesulfonate (6.11 g, 26.8 mmol) in a similar manner to Step-1 of Amine-10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187475B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-fbd6336f696e4a788dbae0a198b9b22b |
| Source note | uspto-grants-2015_11 |