反应详情

温度

110 °C

A 20 mL microwavable vial was charged with ethyl (6-chloro-4-methylpyridazin-3-yl)carbamate (550 mg, 2.55 mmol) and sodium ethoxide (3.11 mL, 17.85 mmol), then stirred and heated at 110° C. for 12 h. The reaction mixture was then concentrated and partitioned between ammonium chloride and DCM. The layers were separated and the aqueous layers were washed with DCM (2×). The combined organic layers were washed with water, brine, and eluted through a phase separator. The organic layers were concentrated to afford ethyl (6-ethoxy-4-methylpyridazin-3-yl)carbamate (398 mg, 65.8% yield).

1. concentrationThe reaction mixture was then concentrated
2. custompartitioned between ammonium chloride and DCM
3. customThe layers were separated
4. washthe aqueous layers were washed with DCM (2×)
5. washThe combined organic layers were washed with water, brine
6. washeluted through a phase separator
7. concentrationThe organic layers were concentrated