反应详情

温度

50 °C

A mixture of 8-(4-bromophenyl)-1,4-dioxa-8-azaspiro[4.5]decane (1.02 g) and half concentrated hydrochloric acid is heated for 12 hours at 50° C., poured on ice and aqueous NaOH solution (4 M) is added until pH ˜7-8. Then the mixture is extracted with ethylacetate and the organic phase is washed with brine and dried (MgSO4). The solvents are evaporated in vacuo to give the title compound. LC (method 2): tR=0.96 min; Mass spectrum (ESI+): m/z=254 [M+H]+.

1. additionis added until pH ˜7-8
2. extractionThen the mixture is extracted with ethylacetate
3. washthe organic phase is washed with brine
4. dry with materialdried (MgSO4)
5. customThe solvents are evaporated in vacuo