反应详情

温度

0 °C

1-(4-Bromophenyl)piperidin-4-one (765 mg) is dissolved under argon in MeOH (8 mL), cooled to 0° C. and treated with NaBH4 (145 mg). The mixture is stirred for 2 hours at 0° C., treated with saturated aqueous NaHCO3 solution and stirred for 10 minutes. Then the mixture is extracted with ethylacetate and the organic phase is washed with brine and dried (MgSO4). The solvents are evaporated to give the title compound. LC (method 2): tR=0.92 min; Mass spectrum (ESI+): m/z=256 [M+H]+.

1. stirringstirred for 10 minutes
2. extractionThen the mixture is extracted with ethylacetate
3. washthe organic phase is washed with brine
4. dry with materialdried (MgSO4)
5. customThe solvents are evaporated