HCID 118037353, compound → HCID 20735409, compound

HRID 715585Notes

Reaction equation

HRID 715585 reaction equation
[CH:1]([NH:4][C:5]([O:7][CH:8]1[CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10][CH2:9]1)=[O:6])([CH3:3])[CH3:2].[H][H]>C(O)C.[Pd]>[CH:1]([NH:4][C:5](=[O:6])[O:7][CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 118037353HCID 118037353, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20735409HCID 20735409, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Benzyl 4-(isopropylcarbamoyloxy)piperidine-1-carboxylate (113 mg) is dissolved in ethanol (3 mL), treated with palladium on carbon (10%, 38 mg) and the mixture is hydrogenated at room temperature for 8 hours under 3 bar hydrogen pressure. Then the catalyst is filtered off and washed with ethanol. The combined mother liquours are concentrated to give the title compound, which is used directly in the next step.

Workup

  1. filtrationThen the catalyst is filtered off
  2. washwashed with ethanol
  3. concentrationThe combined mother liquours are concentrated

Sources & evidence

ORD record
ord-54beba9a5a8a4a26bf7bdacda2fdf46b
Source dataset
uspto-grants-2015_11
Patent number
US09187477B2

Reaction notes

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