反应详情

温度

65 °C

15 g 4-Fluoro-3-methoxybenzonitrile and 12 mL 3-dimethylamino-1-propanol was dissolved 150 mL tetrahydrofuran. 21.7 g Potassium hexamethyldisilazide was added and the mixture was stirred at 65° C. for 6 h. the mixture was concentrated to 50 mL and the residue diluted in ethyl acetate, washed with water and saturated sodium chloride solution and the organic phase dried over magnesium sulfate.

1. concentrationwas concentrated to 50 mL
2. additionthe residue diluted in ethyl acetate
3. washwashed with water and saturated sodium chloride solution
4. dry with materialthe organic phase dried over magnesium sulfate