Lithium borohydride → 1319736-87-2

HRID 715699Notes

Reaction equation

HRID 715699 reaction equation
[O:1]=[C:2]1[NH:6][CH2:5][CH:4]([CH2:7][C:8](OC)=[O:9])[CH2:3]1.[BH4-].[Li+]>O1CCCC1.[Cl-].[Na+]>[OH:9][CH2:8][CH2:7][CH:4]1[CH2:5][NH:6][C:2](=[O:1])[CH2:3]1

Participants

5

Reactant 2

HCID 4148881Lithium borohydrideHCID 54291197HCID 54291197, compound

Product 1

HCID 184645611319736-87-2

Reagents, catalysts & solvents 2

HCID 5234Sodium ChlorideSolventHCID 8028TetrahydrofuranSolvent

Procedure

100 mg Methyl 2-(5-oxopyrrolidine-3-yl)acetate (I.26) was placed in tetrahydrofuran and 30 mg lithium borohydride was added and the mixture stirred at ambient temperature overnight. The suspension was diluted with saturated sodium chloride solution and extracted with ethyl acetate (×3). The water phase was freeze dried.

Workup

  1. extractionextracted with ethyl acetate (×3)
  2. customdried

Sources & evidence

ORD record
ord-ec073b1cc3d542eca4b3b0c39cd3d39c
Source dataset
uspto-grants-2015_11
Patent number
US09187478B2

Reaction notes

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