Lithium Hydroxide → N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamine

HRID 71571Notes

Reaction equation

HRID 71571 reaction equation
C(C1C=CC(NC2C(F)=CN=C(NC3C=CC4OC(C(O)=O)CC=4C=3)N=2)=CC=1)(C)(C)C.[CH2:32]1[CH2:41][O:40][C:39]2[CH:38]=[CH:37][C:36]([NH:42][C:43]3[C:48]([F:49])=[CH:47][N:46]=[C:45]([NH:50][C:51]4[CH:52]=[CH:53][C:54]5[O:58][C:57]([C:59]([O:61]C)=[O:60])=[CH:56][C:55]=5[CH:63]=4)[N:44]=3)=[CH:35][C:34]=2[O:33]1.[Li+].[OH-]>>[CH2:32]1[CH2:41][O:40][C:39]2[CH:38]=[CH:37][C:36]([NH:42][C:43]3[C:48]([F:49])=[CH:47][N:46]=[C:45]([NH:50][C:51]4[CH:52]=[CH:53][C:54]5[O:58][C:57]([C:59]([OH:61])=[O:60])=[CH:56][C:55]=5[CH:63]=4)[N:44]=3)=[CH:35][C:34]=2[O:33]1

Participants

4

Reactant 3

HCID 3939Lithium HydroxideHCID 22060366N4-(4-tert-butylphenyl)-5-fluoro-N2-(2,3-dihydro-2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamineHCID 66758836N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine

Product 1

HCID 66759209N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamine

Procedure

In a manner similar to the preparation of N4-(4-tert-butylphenyl)-5-fluoro-N2-(2,3-dihydro-2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamine, N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-methoxycarbonylbenzofuran-5-yl)-2,4-pyrimidinediamine and LiOH were reacted to yield N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(2-carboxybenzofuran-5-yl)-2,4-pyrimidinediamine.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b567f2eeb6c14f19a827de9da893a943
Source dataset
uspto-grants-2014_09
Patent number
US08822685B2

Reaction notes

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