Sodium Hydroxide → HCID 43935798, compound

HRID 715729Notes

Reaction equation

HRID 715729 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]2[N:11]=[C:12]([S:15][CH2:16][C:17]([O:19]CC)=[O:18])[CH:13]=[CH:14][C:9]2=[N:8][N:7]=1.[OH-].[Na+]>C1COCC1.CO>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]2[N:11]=[C:12]([S:15][CH2:16][C:17]([OH:19])=[O:18])[CH:13]=[CH:14][C:9]2=[N:8][N:7]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 5310124HCID 5310124, compound

Product 1

HCID 43935798HCID 43935798, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To ethyl 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetate (50 mg, 0.156 mmol) dissolved in a 2/1 mixture of THF and MeOH was added 100 uL of 2N NaOH, and the whole was stirred at room temperature for 3 h. The reaction mixture was then evaporated to dryness, the residue dissolved in water (5 mL), and the solution acidified with 6M HCl. The resulting precipitate was filtered, washed twice with cold water, and dried to give acid 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetic acid.

Workup

  1. customThe reaction mixture was then evaporated to dryness
  2. dissolutionthe residue dissolved in water (5 mL)
  3. filtrationThe resulting precipitate was filtered
  4. washwashed twice with cold water
  5. customdried

Sources & evidence

ORD record
ord-fe28e6d9bbee4524b24d9755ededb7a7
Source dataset
uspto-grants-2015_11
Patent number
US09187484B2

Reaction notes

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