Ammonia → HCID 6852074, compound

HRID 715730Notes

Reaction equation

HRID 715730 reaction equation
[NH3:1].[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[N:11]2[N:12]=[C:13]([S:16][CH2:17][C:18]([O:20]CC)=O)[CH:14]=[CH:15][C:10]2=[N:9][N:8]=1>>[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[N:11]2[N:12]=[C:13]([S:16][CH2:17][C:18]([NH2:1])=[O:20])[CH:14]=[CH:15][C:10]2=[N:9][N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 5310124HCID 5310124, compound

Product 1

HCID 6852074HCID 6852074, compound

Conditions

Temperature
92.5 °C

Procedure

Ethanolic ammonia (5 mL) was added to intermediate ethyl 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetate (60 mg, 0.188 mmol), the reaction vessel sealed and the mixture stirred overnight at 90-95° C. The mixture was then evaporated to dryness, the solid residue was filtered, washed 3 times with EtOH, and dried to give the desired 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamide.

Workup

  1. customthe reaction vessel sealed
  2. customThe mixture was then evaporated to dryness
  3. filtrationthe solid residue was filtered
  4. washwashed 3 times with EtOH
  5. customdried

Sources & evidence

ORD record
ord-37ea0e963a2040049919f008f9123dfa
Source dataset
uspto-grants-2015_11
Patent number
US09187484B2

Reaction notes

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