Ammonia → HCID 6852074, compound

Participants

Reaction Conditions

Reaction Steps

Ethanolic ammonia (5 mL) was added to intermediate ethyl 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetate (60 mg, 0.188 mmol), the reaction vessel sealed and the mixture stirred overnight at 90-95° C. The mixture was then evaporated to dryness, the solid residue was filtered, washed 3 times with EtOH, and dried to give the desired 2-((3-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamide.

Provenance & Evidence