Ammonia → HCID 86701048, compound

HRID 715736Notes

Reaction equation

HRID 715736 reaction equation
[NH3:1].[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:13]2[N:14]=[C:15]([S:18][CH:19]([CH2:25][CH3:26])[C:20](OCC)=[O:21])[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1>CO>[F:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:13]2[N:14]=[C:15]([S:18][CH:19]([CH2:25][CH3:26])[C:20]([NH2:1])=[O:21])[CH:16]=[CH:17][C:12]2=[N:11][N:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86701046HCID 86701046, compound

Product 1

HCID 86701048HCID 86701048, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To 10 ml of dry methanol saturated with ammonia was added 0.5 mmol of ethyl 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanoate. The pressure tube was stoppered tightly, and the solution was stirred for 16 hours at 50° C. The white precipitate was collected and washed with cold methanol to give 2-((3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)butanamide.

Workup

  1. customThe white precipitate was collected
  2. washwashed with cold methanol

Sources & evidence

ORD record
ord-af9e65e38fac424782ad5aa9a112d1ce
Source dataset
uspto-grants-2015_11
Patent number
US09187484B2

Reaction notes

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