Trifluoroacetic acid → HCID 86701926, compound

HRID 715751Notes

Reaction equation

HRID 715751 reaction equation
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([NH:10][C:11](=[O:32])[NH:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH:20]=4)=[CH:15][CH:14]=3)[CH:7]=[CH:6][C:5]=12.FC(F)(F)C(O)=O>ClCCl>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([NH:10][C:11]([NH:12][C:13]3[CH:14]=[CH:15][C:16]([C:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH:20]=4)=[CH:17][CH:18]=3)=[O:32])[CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86701927HCID 86701927, compound

Product 1

HCID 86701926HCID 86701926, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 4-(4-(3-imidazo[1,2-a]pyridin-6-ylureido)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (0.57 g, 1.315 mmol) in dichloromethane (5 ml) was treated with trifluoroacetic acid (0.608 ml, 7.88 mmol) and the reaction mixture was stirred at room temperature for 4 hours. Concentration provided the title compound.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-51e9c5bef8df4f07bcb01fe79acd59d2
Source dataset
uspto-grants-2015_11
Patent number
US09187472B2

Reaction notes

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