HRID715952

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID688279

BOC-D-PROLINOL

C10H19NO3

结构：COC(=O)c1c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc(Br)c1O

HCID70983234

未命名化合物

2 次

结构：COC(=O)c1c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)ccc(Br)c1OC[C@H]1CCCN1C(=O)OC(C)(C)C

HCID71003908

未命名化合物

PRODUCTS

生成物

HCID71003911

未命名化合物

PROCEDURE

实验过程

Prepared by proceeding in a similar manner to Intermediate 8, starting from tert-butyl (R)-2-hydroxymethylpyrrolidine-1-carboxylate and methyl 3-bromo-6-bis-(tert-butoxycarbonyl)amino-2-hydroxybenzoate (Intermediate 9).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ac7aa1d2f504c879ae7cb0ce87469a6
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09187494B2
来源说明: uspto-grants-2015_11

反应 SMILES

[Br:1][C:2]1[C:7]([O:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[C:6]([C:22]([O:24][CH3:25])=[O:23])[C:5]([N:26]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:4][CH:3]=1.OC[C@H]1CCCN1C(OC(C)(C)C)=O.BrC1C(O)=C(C(N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)=CC=1)C(OC)=O>>[Br:1][C:2]1[C:7]([O:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])=[C:6]([C:22]([O:24][CH3:25])=[O:23])[C:5]([N:26]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:34]([O:36][C:37]([CH3:39])([CH3:38])[CH3:40])=[O:35])=[CH:4][CH:3]=1