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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 715952Generated: October 30, 2026

N-(tert-Butoxycarbonyl)-D-prolinol → tert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/715952

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(tert-Butoxycarbonyl)-D-prolinolHCID 688279—
ReactantMethyl 3-bromo-6-bis-(tert-butoxycarbonyl)amino-2-hydroxybenzoateHCID 70983234—
Reactanttert-butyl (R)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxymethyl]pyrrolidine-1-carboxylateHCID 71003908—
Producttert-butyl (S)-2-[6-bromo-3-bis-(tert-butoxycarbonyl)amino-2-methoxycarbonylphenoxy-methyl]pyrrolidine-1-carboxylateHCID 71003911—

Reaction Steps

Prepared by proceeding in a similar manner to Intermediate 8, starting from tert-butyl (R)-2-hydroxymethylpyrrolidine-1-carboxylate and methyl 3-bromo-6-bis-(tert-butoxycarbonyl)amino-2-hydroxybenzoate (Intermediate 9).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187494B2
Source datasetuspto-grants-2015_11
ORD IDord-7ac7aa1d2f504c879ae7cb0ce87469a6
Source noteuspto-grants-2015_11