Trifluoroacetic acid → Alanine--lysine (1/1)

참여 물질

반응 단계

To the poly-L-alanine/Nε-benzyloxycarbonyl-L-lysine copolymer (9/1) obtained in Production Example 16 were added 270 equivalents and 5 equivalents of trifluoroacetic acid (manufactured by TOKYO CHEMICAL INDUSTRY CO., LTD.) and thioanisole (manufactured by TOKYO CHEMICAL INDUSTRY CO., LTD.), respectively, relative to the number of moles of N-carboxy-N′-benzyloxycarbonyl-L-lysine anhydride, and the mixture was reacted at room temperature to give a poly-L-alanine/L-lysine copolymer. This was dissolved in a dichloromethane-trifluoroacetic acid mixed solvent (50:70 (v/v)) to give a 4.4 wt % poly-L-alanine/L-lysine copolymer solution. A fiber structure made of a poly-L-alanine/L-lysine copolymer was obtained from this solution in the same manner as in Production Example 1.

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