反应详情

温度

100 °C

A suspension of 70.70 g of cloquintocet-mexyl (96.9% strength) in 205 g of demineralised water was stirred at 100° C. in a 1 L jacketed glass vessel. 27.5 g of aqueous hydrochloric acid [32%] was slowly added, and the reaction mixture was stirred under reflux for 6 hours. The biphasic solution was then cooled down to 20° C. over 4 hours and the resulting suspension was filtered and the solid was wash with 2×50 mL of demineralised water and dried. Cloquintocet acid hydrochloride (35.55 g) was isolated as a light brown solid.

1. stirringthe reaction mixture was stirred
2. temperatureunder reflux for 6 hours
3. temperatureThe biphasic solution was then cooled down to 20° C. over 4 hours
4. filtrationthe resulting suspension was filtered
5. washthe solid was wash with 2×50 mL of demineralised water
6. customdried