2-Propanesulfonyl chloride → Tert-butyl 2-(3-(1-methylethylsulfonamido)phenoxy)ethylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	2-Propanesulfonyl chloride	HCID 82408	—
Reactant	tert-butyl N-[2-(3-aminophenoxy)ethyl]carbamate	HCID 11557882	—
Product	Tert-butyl 2-(3-(1-methylethylsulfonamido)phenoxy)ethylcarbamate	HCID 68524470	—

Reaction Steps

Sulfonation of tert-butyl 2-(3-aminophenoxy)ethylcarbamate (3) using propane-2-sulfonyl chloride following the method described in Example 1 gave tert-butyl 2-(3-(1-methylethylsulfonamido)phenoxy)ethylcarbamate (7) as a light yellow oil. 1H NMR (400 MHz, DMSO-d6) δ 9.70 (s, 1H), 7.17 (t, J=8.0 Hz, 1H), 6.97 (t, J=6.0 Hz, 1H), 6.76-6.79 (m, 2H), 6.60-6.62 (m, 1H), 3.16-3.30 (m, 3H), 1.35 (s, 9H), 1.19 (d, J=6.8 Hz, 6H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09193669B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-360d0a2753a94e399cd17cf0c78a4a61
Source note	uspto-grants-2015_11