Pentanal → 3-Hydroxy-3-(3-(pentylamino)phenyl)propanenitrile

HRID 716753Notes

Reaction equation

HRID 716753 reaction equation
[OH:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)[CH2:3][C:4]#[N:5].[CH:15](=O)[CH2:16][CH2:17][CH2:18][CH3:19]>>[OH:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH:7]=1)[CH2:3][C:4]#[N:5]

Participants

3

Reactant 2

HCID 8063PentanalHCID 593169073-Hydroxy-3-(3-nitrophenyl)propanenitrile

Product 1

HCID 672965943-Hydroxy-3-(3-(pentylamino)phenyl)propanenitrile

Procedure

Hydrogenation of nitrobenzene 11 (0.8 g, 4.2 mmol) and pentanal (0.45 ml, 4.2 mmol) following method described in Example 11 gave 3-hydroxy-3-(3-(pentylamino)phenyl)propanenitrile as a light yellow oil. Yield (0.90 g, 77%).

Sources & evidence

ORD record
ord-d7299af33ee040cfb96b132c95129a38
Source dataset
uspto-grants-2015_11
Patent number
US09193669B2

Reaction notes

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