1-Oxaspiro(2.4)heptane → 3-Hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile

HRID 716787Notes

Reaction equation

HRID 716787 reaction equation
[O:1]1[C:3]2([CH2:7][CH2:6][CH2:5][CH2:4]2)[CH2:2]1.[NH2:8][C:9]1[CH:10]=[C:11]([CH:15]([OH:19])[CH2:16][C:17]#[N:18])[CH:12]=[CH:13][CH:14]=1>>[OH:19][CH:15]([C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([NH:8][CH2:2][C:3]2([OH:1])[CH2:7][CH2:6][CH2:5][CH2:4]2)[CH:10]=1)[CH2:16][C:17]#[N:18]

Participants

3

Reactant 2

HCID 6379911-Oxaspiro(2.4)heptaneHCID 593169603-(3-Aminophenyl)-3-hydroxypropanenitrile

Product 1

HCID 672967103-Hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile

Procedure

Reaction between 1-oxaspiro[2.4]heptane and aniline 12 gives 3-hydroxy-3-(3-((1-hydroxycyclopentyl)methylamino)phenyl)propanenitrile.

Sources & evidence

ORD record
ord-78983b14ab8c4670b6aa5c63a45d1f64
Source dataset
uspto-grants-2015_11
Patent number
US09193669B2

Reaction notes

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