反应详情

A solution of 1,3-dihydro-2-benzofuran-5-ol (Intermediate 73, 100 mg, 0.734 mmol), 1-fluoro-4-nitrobenzene (109 mg, 0.771 mmol) and potassium carbonate (508 mg, 3.67 mmol) in acetonitrile (10 ml) was stirred under argon at 100° C. in a closed vial for 2 hours. The solid was filtered and washed with dichloromethane. The organic phase was concentrated under vacuum to afford title compound (184 mg, 96% yield)

1. filtrationThe solid was filtered
2. washwashed with dichloromethane
3. concentrationThe organic phase was concentrated under vacuum