反应详情

温度

125 °C

A solution of methyl 3-bromo-2-phenylquinoxaline-6-carboxylate (150 mg, 0.44 mmol, 1.00 equiv) and piperazine (77.4 mg, 0.90 mmol, 2.00 equiv) in DMSO (8 mL) was placed in a 20-mL sealed tube, stirred for 3 hrs at 125° C. in an oil bath, and then quenched by the addition of 50 mL of water. The resulting solution was extracted with 6×50 mL of dichloromethane, the organic layers combined and dried over anhydrous sodium sulfate, and the solution filtered to remove solids. Concentration under vacuum yielded 160 mg (91%) of methyl 2-phenyl-3-(piperazin-1-yl)quinoxaline-6-carboxylate as a yellow solid.

1. customsealed tube
2. customquenched by the addition of 50 mL of water
3. extractionThe resulting solution was extracted with 6×50 mL of dichloromethane
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationthe solution filtered
6. customto remove solids
7. concentrationConcentration under vacuum