Diisopropylethylamine → HCID 66620299, compound

HRID 71701Notes

Reaction equation

C[O:2][C:3]([C:5]1[C:6]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[NH:28][C:29]([CH:32]4[CH2:36][CH2:35][CH2:34][NH:33]4)=[N:30][CH:31]=3)=[CH:23][C:22]=2[CH2:37][NH:38][CH3:39])=[CH:7][CH:8]=[C:9]([C:11]2[NH:12]C(C3CCCN3)=[N:14][CH:15]=2)[CH:10]=1)=O.C([N:43]([CH:46]([CH3:48])[CH3:47])[CH2:44][CH3:45])(C)C>N1C=CC=CC=1>[CH3:39][N:38]1[CH2:37][C:22]2[CH:23]=[C:24]([C:27]3[NH:28][C:29]([CH:32]4[CH2:36][CH2:35][CH2:34][NH:33]4)=[N:30][CH:31]=3)[CH:25]=[CH:26][C:21]=2[C:6]2[CH:7]=[CH:8][C:9]([C:11]3[NH:12][C:48]([CH:46]4[CH2:47][CH2:45][CH2:44][NH:43]4)=[N:14][CH:15]=3)=[CH:10][C:5]=2[C:3]1=[O:2]

Participants

Conditions

Temperature: 100 °C

Procedure

To the solution of 2′-methylaminomethyl-4,4′-bis-(2-pyrrolidin-2-yl-3H-imidazol-4-yl)-biphenyl-2-carboxylic acid methyl ester (90 mg) in pyridine (5 ml) was added diisopropylethylamine (1 ml). The mixture was heated at 100° C. for 2 hours. The solvents were evaporated. The mixture was diluted with acetonitrile and water, was freezer-dried to give 6-Methyl-3,9-bis-(2-pyrrolidin-2-yl-3H-imidazol-4-yl)-6,7-dihydro-dibenzo[c,e]azepin-5-one as brown powder. m/z: 494.1 (M+H)+.

Workup

customThe solvents were evaporated
additionThe mixture was diluted with acetonitrile and water
customwas freezer-dried

Sources & evidence

ORD record: ord-cb8f7d11aff84f6f9043c19d083d0d24
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822430B2

Reaction notes

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