反应详情

温度

160 °C

The suspension of (4,4′-dibromo-2′-hydroxymethyl-biphenyl-2-yl)-methanol (460 mg) in phosphoric acid (25 ml) was heated at 160° C. for 4 hours. The mixture was cooled and diluted with water (100 ml), and was extracted with EtOAC. The organic phase was washed with water, saturated sodium bicarbonate, and brine, and was dried with sodium sulfate. Concentration yielded 3,9-dibromo-5,7-dihydro-dibenzo[c,e]oxepine (416 mg).

1. temperatureThe mixture was cooled
2. extractionwas extracted with EtOAC
3. washThe organic phase was washed with water, saturated sodium bicarbonate, and brine
4. dry with materialwas dried with sodium sulfate
5. concentrationConcentration