4,4'-Dibromo-2,2'-bis-hydroxymethyl-biphenyl → 3,9-Dibromo-5,7-dihydrodibenzo[c,e]oxepine

関与物質

反応条件

反応手順

The suspension of (4,4′-dibromo-2′-hydroxymethyl-biphenyl-2-yl)-methanol (460 mg) in phosphoric acid (25 ml) was heated at 160° C. for 4 hours. The mixture was cooled and diluted with water (100 ml), and was extracted with EtOAC. The organic phase was washed with water, saturated sodium bicarbonate, and brine, and was dried with sodium sulfate. Concentration yielded 3,9-dibromo-5,7-dihydro-dibenzo[c,e]oxepine (416 mg).

情報源と証拠