反应详情

To 4-(5-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl)-benzonitrile (100 mg, 0.38 mmol) was added 2M NaOH (1.5 mL) and the reaction mixture irradiated using a microwave (300 W, 130° C., 20 min). The reaction mixtures was diluted with water and adjusted to pH2 with 2M HCl whereupon a pale yellow solid precipitated out of solution. The solid was filtered, washed with water and dried. The solid was dissolved in DMF and passed through a Si-thiol cartridge to remove any residual palladium, eluting with DMF. The eluent was removed in vacuo to give 4-(5-methyl-1-oxo-1,2-dihydro-isoquinolin-3-yl)-benzoic acid as a pale yellow solid (120 mg, 63%).

1. customthe reaction mixture irradiated
2. customa microwave (300 W, 130° C., 20 min)
3. customThe reaction mixtures
4. customprecipitated out of solution
5. filtrationThe solid was filtered
6. washwashed with water
7. customdried
8. dissolutionThe solid was dissolved in DMF
9. customto remove any residual palladium
10. washeluting with DMF
11. customThe eluent was removed in vacuo